Introduction. Tendon adhesion to surrounding tissues is the most common complication reported after tendon repair. To date,\neffective solutions to prevent tendon injury are still lacking. Materials and Methods. A total of 89 patients with flexor tendon injury\nin zone II were recruited.The patients were divided into a control group, a poly-DL-lactic acid (PDLLA) group, and an amnion\ngroup according to the different tendon treatments applied. The control group was not subjected to other treatments. PDLLA\nand bioamniotic membranes were, respectively, used to wrap broken ends in the PDLLA and amnion membrane groups. The\npatients were followed at 1, 2, 3, 6, and 12 months after surgery and the ranges of active flexion and extension lag in the proximal\nand distal interphalangeal joints were evaluated. Results.The means of total active ranges of motion of the interphalangeal joints\n(excluding rupture cases) in the PDLLA and amnion groups did not significantly differ between each other but significantly differed\nfrom that of the control group. Statistical analysis showed a significant difference in the clinical grades of the outcomes among the\ncontrol, PDLLA, and amnion groups.Theincidence of complications in the control and PDLLAgroups was found to be significantly\nhigher than that in the amniotic membrane group; no significant difference was observed between the control and PDLLA groups.\nConclusion. In this study, freeze-dried amniotic membrane transplantation was applied to promote healing of the flexor tendon in\nzone II and prevent adhesion. This technique presents a newmethod to solve the issue of tendon adhesion after repair. Clinical Trial\nRegistration.The trial was registered by identifier ChiCTR1900021769.
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